Imidazopyrimidine derivatives

A compound of formula (I′)

• wherein
• R1 is phenyl or thienyl, wherein said phenyl and said thienyl are optionally substituted by 1 to 3 substituents independently selected from the group consisting of halogen, lower alkyl, lower alkoxy, lower haloalkyl, lower haloalkoxy and lower alkoxy lower alkyl;
• R2 is 5- or 6-membered monocyclic heteroaryl having 1 to 3 heteroatoms independently selected from N and O, wherein said heteroaryl is optionally substituted by 1 to 3 substituents independently selected from the group consisting of
• halogen, hydroxyl, nitro, lower alkyl, lower alkoxy, lower alkoxy-C(O)—, lower hydroxyalkyl, lower haloalkyl, lower alkoxy lower alkyl, lower alkyl-C(O)—, cycloalkyl, heterocyclyl, aryl, heteroaryl and amino optionally substituted by heteroaryl, wherein two substituents of R2, together with said heteroaryl to which they are attached, may form a 9- or 10-membered bicyclic ring;
• and
• R3 and R3′ are each independently hydrogen, lower alkyl optionally substituted by cycloalkyl, lower hydroxyalkyl, lower cyanoalkyl, lower haloalkyl, lower alkoxy lower alkyl, cycloalkyl or heterocyclyl, or
• R3 and R3′, together with the nitrogen atom to which they are attached, form a heterocyclyl optionally substituted by 1 to 3 halogen, hydroxyl or oxo;
• or a pharmaceutically acceptable salt thereof.

A pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (I)

• wherein
• R1 is phenyl or thienyl, wherein said phenyl and said thienyl are optionally substituted by 1 to 3 substituents independently selected from the group consisting of hydroxyl, halogen, lower alkyl, lower alkoxy, lower haloalkyl, lower haloalkoxy, lower alkoxy lower alkyl, —OC(O)-lower alkyl, —OCH2C(O)-lower alkoxy and phenyl;
• R2 is 5- or 6-membered monocyclic heteroaryl having 1 to 3 heteroatoms independently selected from N and O, wherein said heteroaryl is optionally substituted by 1 to 3 substituents independently selected from the group consisting of
• halogen, hydroxyl, nitro, lower alkyl, lower alkenyl, lower alkoxy, lower alkoxy-C(O)—, lower hydroxyalkyl, lower haloalkyl, lower alkoxy lower alkyl, lower alkyl-C(O)—, cycloalkyl, heterocyclyl, aryl, heteroaryl and amino optionally substituted by heteroaryl, wherein two substituents of R2, together with said heteroaryl to which they are attached, may form a 9- or 10-membered bicyclic ring;
• R3 and R3′ are each independently hydrogen, lower alkyl, lower hydroxyalkyl, lower cyanoalkyl, lower haloalkyl, lower alkoxy lower alkyl, cycloalkyl, cyanocycloalkyl, heterocyclyl or aryl, wherein said lower alkyl is optionally substituted by lower haloalkoxy, cycloalkyl, aryl or heteroaryl, wherein said heteroaryl is optionally substituted by 1 to 3 substituents independently selected from the group consisting of halogen, nitro, cyano, lower alkyl, lower haloalkyl, lower alkoxy and cycloalkyl, and wherein said heterocyclyl is optionally substituted by lower alkyl, or
• R3 and R3′, together with the nitrogen atom to which they are attached, form a heterocyclyl, 2,5-dihydro-1H-pyrrole, 2-methyl-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole or 2-oxa-6-azaspiro[3.3]heptane, wherein said heterocyclyl is optionally substituted by 1 to 3 halogen, hydroxyl, oxo, lower alkyl or heteroaryl;
• and
• R8 is hydrogen, lower alkyl, lower alkoxy or lower alkoxy lower alkyl;
• or a pharmaceutically acceptable salt thereof
• and a pharmaceutically acceptable carrier.