US 8,410,116 B2 · Bis(styryl)pyrimidine or bis(styryl)benzene compounds, pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition for prevention or treatment of diseases featuring amyloids comprising the same as an active ingredient

Abstract

Disclosed are bis(styryl)pyrimidine or bis(styryl)benzene compounds, represented by Chemical Formula 1, pharmaceutically acceptable salts, a method for preparing the same, and a pharmaceutical composition for the prevention and treatment of amyloidosis-associated diseases, comprising the same as an active ingredient. Having the ability to inhibit the deposition of beta amyloid and to reduce the toxicity of beta amyloid, the derivatives can improve learning and memory and can be useful in the prevention and treatment of amyloidosis-associated diseases. (wherein R1, R2, R3 and X are as defined in the specification).

Claims15

Dependent claims

A compound of bis(styryl)pyrimidine, represented by the following Chemical Formula 1, or pharmaceutically acceptable salts thereof:

Wherein
x is nitrogen;
R1 is selected from the group consisting of methoxy, ethoxy, propyloxy, butyloxy;
and
R2 and R3 are independently selected from hydrogen, hydroxy, methoxy, ethoxy, propoxy, butoxy, dimethylamino, diethylamino, dipropylamino, and dibutylamino.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

12/429,552Filed 24 Apr 2009

Priority

KR 10-2009-000609223 Jan 2009

Published

US 2010/0190803 A129 Jul 2010

Granted

2 Apr 2013

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

C07D 239/26
Having three or more double bonds between ring members or between ring members and non-ring members: with only hydrogen atoms, hydrocarbon or…
A61K 9/2018
Organic compounds, e.g. phospholipids, fats: sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
A61K 9/2059
Polysaccharides, e.g. alginate, gums; Cyclodextrin: starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
A61K 9/4858
Filling excipients; Inactive ingredients: organic compounds

Bis(styryl)pyrimidine or bis(styryl)benzene compounds, pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition for prevention or treatment of diseases featuring amyloids comprising the same as an active ingredient

Life of this patent

Bis(styryl)pyrimidine or bis(styryl)benzene compounds, pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition for prevention or treatment of diseases featuring amyloids comprising the same as an active ingredient

Life of this patent

Abstract

Claims15