Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices

A compound selected from

• 2-(4-hydroxy-3,5-dimethylphenyl)-4H-pyrano[2,3-b]pyridin-4-one;
• 7-((dimethylamino)methyl)-2-(4-hydroxyphenyl)-4H-pyrano[2,3-b]pyridin-4-one dihydrochloride;
• 2-(4-(2-(dimethylamino)ethoxy)phenyl)-4H-pyrano[2,3-b]pyridin-4-one dihydrochloride;
• 2-(4-hydroxy-3-(thiophen-2-yl)phenyl)-4H-pyrano[2,3-b]pyridin-4-one;
• 2-(2,6-dimethyl-4-(4-oxo-4H-pyrano[2,3-b]pyridin-2-yl)phenoxy)acetic acid;
• 2-(3,5-dimethyl-4-(2-morpholinoethoxy)phenyl)-4H-pyrano[2,3-b]pyridin-4-one hydrochloride;
• 2-(4-hydroxy-3,5-dimethylphenyl)-6-(pyrrolidin-1-ylmethyl)-4H-pyrano[2,3-b]pyridin-4-one dihydrochloride;
• 6-(4-oxo-4H-chromen-2-yl)benzo[d]oxazol-2(3H)-one;
• 2-(4-fluorophenyl)-6-(pyrrolidin-1-ylmethyl)-4H-pyrano[2,3-b]pyridin-4-one hydrochloride;
• 2-(4-isopropoxyphenyl)-6-(pyrrolidin-1-ylmethyl)-4H-pyrano[2,3-b]pyridin-4-one hydrochloride;
• 7-(4-hydroxy-3,5-dimethylphenyl)-1,6-naphthyridin-5(6H)-one hydrochloride;
• 2-hydroxy-7-(4-hydroxy-3,5-dimethylphenyl)-4-methoxy-1,6-naphthyridin-5(6H)-one dihydrochloride;
• 3-(4-(2-hydroxy-2-methylpropoxy)-3,5-dimethylphenyl)-6,8-dimethoxyisoquinolin-1(2H)-one;
• 2,6-dimethyl-4-(1-(methylamino)-7-((4-methylpiperazin-1-yl)methyl)isoquinolin-3-yl)phenol trihydrochloride;
• 2-(quinoxalin-6-yl)-4H-pyrano[2,3-b]pyridin-4-one;
• 4-(5-amino-2,4-dimethoxy-1,6-naphthyridin-7-yl)-2,6-dimethylphenol;
• 2-(4-fluorophenyl)-6-(morpholinomethyl)quinazolin-4(3H)-one;
• 2-(1H-indazol-5-yl)-6-(morpholinomethyl)-4H-pyrano[2,3-b]pyridin-4-one;
• 3-(3,5-dimethyl-4-(2-morpholinoethoxy)phenyl)-6,8-dimethoxyisoquinolin-1(2H)-one;
• and
• 6-((dimethylamino)methyl)-2-(pyridin-4-yl)-4H-chromen-4-one, and pharmaceutically acceptable salts thereof.