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US 8,410,107 B2Granted
N-pyridin-3-yl or N-pyrazin-2-yl carboxamides
AssigneeHoffmann-La Roche Inc.
InventorsUwe Grether, Paul Hebeisen, Torsten Hoffmann, Stephan Roever
Life of this patent
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Abstract
The present invention relates to compounds of formula I, wherein A, R1 to R7 are defined in the description, and to pharmaceutically acceptable salts thereof. The present invention also relates to the manufacture of such compounds or their pharmaceutically acceptable salts, pharmaceutical compositions containing them and their use as medicaments for the treatment and/or prophylaxis of diseases which can be treated with HDL-cholesterol raising agents, such as dyslipidemia, atherosclerosis and cardiovascular diseases.
Claims14
A compound according to formula I,
- wherein
- A is CH or N;
- R1 is selected from the group consisting of
- lower alkyl,
- cycloalkyl,
- lower cycloalkylalkyl,
- lower hydroxyalkyl,
- lower alkoxyalkyl,
- lower halogenalkyl,
- lower carbamoylalkyl,
- lower alkylcarbonylaminoalkyl,
- lower phenylalkyl,
- lower heterocyclylalkyl wherein the heterocyclyl group is unsubstituted or substituted by oxo,
- lower heteroarylalkyl wherein the heteroaryl group is unsubstituted or mono- or di-substituted by lower alkyl, and
- phenyl which is unsubstituted or mono- or di-substituted by halogen;
- R2 and R6 independently from each other are hydrogen or halogen;
- R3 and R5 independently from each other are selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, halogen, lower halogenalkyl, lower halogenalkoxy and cyano;
- R4 is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, halogen, lower halogenalkyl, lower halogenalkoxy, amino, azido and cyano;
- and
- R7 is selected from the group consisting of
- lower alkyl,
- lower hydroxyalkyl, lower alkoxyalkyl,
- lower hydroxyimino-alkyl, lower alkoxyimino-alkyl,
- lower cycloalkyl, said cycloalkyl being unsubstituted or substituted by hydroxy, lower heterocyclyl,
- phenyl, said phenyl being unsubstituted or substituted by one or two groups selected from the group consisting of lower alkyl, hydroxy, lower alkoxy, cyano, lower alkylaminocarbonyl and halogen, and
- heteroaryl, said heteroaryl being unsubstituted or substituted by one or two groups selected from the group consisting of lower alkyl, hydroxy, lower alkoxy, cyano, lower alkylaminocarbonyl and halogen;
- or a pharmaceutically acceptable salt thereof.
24 more elements
Dependencies are inferred from the claim text.