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US 8,410,099 B2Granted
Substituted 1-benzyl-cinnolin-4(1H)-one derivatives, preparation thereof, and therapeutic use thereof
AssigneeSanofi
InventorsClaude Vernhet, Elodie Barbagallo, Murielle Rinaldi-Carmona, Pascale Roux
Life of this patent
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Abstract
The present invention is related to novel substituted 1-benzylcinnolin-4(1H)-one derivatives having affinity for cannabinoid CB2 receptors, their preparation and their therapeutic application.
Claims9
A compound of formula (I):
- wherein:
- R1 represents:
- a phenyl which is unsubstituted or substituted one or more times by substituents chosen independently from a halogen atom, an Alk group, an OAlk group, a cyano, an —NH SO2Alk group and an —SO2Alk group;
- a naphthyl which is unsubstituted or substituted one or more times by substituents chosen independently from a halogen atom, an Alk group and an OAlk group;
- a pyridyl which is unsubstituted or substituted one or more times by substituents chosen independently from a halogen atom, an Alk group and an OAlk group;
- a 1-benzothienyl which is unsubstituted or substituted one or more times by substituents chosen independently from a halogen atom, an Alk group and an OAlk group;
- or
- a 1,3-benzodioxolyl which is unsubstituted or substituted one or more times by substituents chosen independently from a halogen atom, an Alk group and an OAlk group;
- R2 represents:
- a phenyl which is unsubstituted or substituted once or twice by substituents chosen independently from a halogen atom, an Alk group and a cyano;
- or
- a thienyl or a pyridyl, each of which is substituted by a halogen atom or an Alk group;
- R3 represents a hydrogen atom, a halogen atom, an Alk group or an OAlk group;
- and
- Alk represents a (C1-C4)alkyl which is unsubstituted or substituted one or more times by a fluorine atom;
- or an acid addition salt thereof.
13 more elements
Dependencies are inferred from the claim text.