Back to results
US 8,410,090 B2Granted
Heterocyclylamide-substituted thiazoles, pyrroles and thiophenes
AssigneeAiCuris GmbH & Co. KG
InventorsHolger Zimmermann, David Brueckner, Kerstin Henninger, Martin Hendrix, Martin Radtke
Life of this patent
Estimating the term…
Abstract
The invention relates to heterocyclylamide-substituted thiazoles, pyrroles and thiophenes and processes for their preparation, to pharmaceutical compositions containing them, and to their use for the treatment and/or prophylaxis of diseases, in particular for the use as antiviral agents, especially against cytomegaloviruses.
Claims6
A compound of the formula
- in which
- R1 represents a group of the formula
- where
- * represents the point of attachment to the carbonyl group,
- R3 represents phenyl or 5- or 6-membered heteroaryl,
- where phenyl and heteroaryl may be substituted by 1 to 3 substituents, where the substituents independently of one another are selected from the group consisting of halogen, hydroxyl, oxo, nitro, cyano, trifluoromethyl, difluoromethyl, trifluoromethoxy, difluoromethoxy, monofluoromethoxy, trifluoromethylthio, C1-C6-alkyl, C1-C6-alkoxy, hydroxycarbonyl, C1-C6-alkoxycarbonyl, amino, C1-C6-alkylamino, aminocarbonyl and C1-C6-alkylaminocarbonyl,
- R4 represents phenyl or 5- or 6-membered heteroaryl,
- where phenyl and heteroaryl may be substituted by 1 to 3 substituents, where the substituents independently of one another are selected from the group consisting of halogen, hydroxyl, oxo, nitro, cyano, trifluoromethyl, difluoromethyl, trifluoromethoxy, difluoromethoxy, monofluoromethoxy, trifluoromethylthio, C1-C6-alkyl, C1-C6-alkoxy, hydroxycarbonyl, C1-C6-alkoxycarbonyl, amino, C1-C6-alkylamino, aminocarbonyl and C1-C6-alkylaminocarbonyl,
- and
- R5 and R6 independently of one another represent hydrogen, methyl or ethyl,
- R2 represents phenyl,
- where phenyl may be substituted by 1 to 3 substituents, where the substituents independently of one another are selected from the group consisting of halogen, hydroxyl, trifluoromethyl, difluoromethyl, trifluoromethoxy, difluoromethoxy, monofluoromethoxy, trifluoromethylthio, C1-C6-alkyl and C1-C6-alkoxy,
- A represents a group of the formula
- where
- * represents the point of attachment to the carbonyl group,
- # represents the point of attachment to the nitrogen atom of the urea,
- R7 represents C1-C6-alkyl,
- where alkyl may be substituted by one substituent, where the substituent is selected from the group consisting of C3-C6-cycloalkyl, C6-C10-aryl and 5- or 6-membered heteroaryl,
- where cycloalkyl, aryl and heteroaryl may be substituted by 1 to 3 substituents, where the substituents independently of one another are selected from the group consisting of halogen, hydroxyl, oxo, nitro, cyano, trifluoromethyl, difluoromethyl, trifluoromethoxy, difluoromethoxy, monofluoromethoxy, trifluoromethylthio, C1-C6-alkyl, C1-C6-alkoxy, hydroxycarbonyl, C1-C6-alkoxycarbonyl, amino, C1-C6-alkylamino, aminocarbonyl and C1-C6-alkylaminocarbonyl,
- and
- R8 and R9 represent, independently of one another, hydrogen, halogen or C1-C6-alkyl,
- where alkyl may be substituted by one substituent, where the substituent is selected from the group consisting of C3-C6-cycloalkyl, C6-C1o-aryl and 5- or 6-membered heteroaryl,
- in which cycloalkyl, aryl and heteroaryl may be substituted by 1 to 3 substituents, where the substituents independently of one another are selected from the group consisting of halogen, hydroxyl, oxo, nitro, cyano, trifluoromethyl, difluoromethyl, trifluoromethoxy, difluoromethoxy, monofluoromethoxy, trifluoromethylthio, C1-C6-alkyl, C1-C6-alkoxy, hydroxycarbonyl, C1-C6-alkoxycarbonyl, amino, C1-C6-alkylamino, aminocarbonyl and C1-C6-alkylaminocarbonyl,
- or a salt thereof.
21 more elements
Dependencies are inferred from the claim text.