Fused heterocyclic ring compound
AssigneeTakeda Pharmaceutical Company Limited
InventorsKentaro Rikimaru, Hiroshi Imoto, Masahiro Kamaura
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AssigneeTakeda Pharmaceutical Company Limited
InventorsKentaro Rikimaru, Hiroshi Imoto, Masahiro Kamaura
Estimating the term…
A compound represented by the following formula or a salt thereof, which has an GPR119 agonist action, is useful for the prophylaxis or treatment of diabetes, obesity and the like, and shows superior efficacy: wherein P: substituted 6-membered aromatic ring, Q: (substituted) 6-membered aromatic ring, A1: CR4aR4b, NR4c, O, S, SO or SO2 {R4a-4c: H etc.}, L1: (substituted) C1-5 alkylene, L2: a bond or (substituted) C1-3 alkylene, L3-4: (substituted) C1-3 alkylene, R1: H, X, CN, (substituted) hydrocarbon, (substituted) heterocycle or (substituted) OH, or (substituted) 4- to 8-membered (heterocyclic) ring together with A1, R2: H, CN, (substituted) hydrocarbon, and R3a: —COSRA1, (substituted) 5- or 6-membered aromatic ring {RA1: (substituted) hydrocarbon or (substituted) heterocycle}.
A compound represented by the formula:
1-[6-({1-[3-(1-Methylethyl)-1,2,4-oxadiazol-5-yl]piperidin-4-yl}oxy)pyrimidin-4-yl]-5-(methylsulfonyl)-2,3-dihydro-1H-indole or a salt thereof.
S-(1-Methylethyl)4-[(6-{5-[(hydroxyacetyl)amino]-2,3-dihydro-1H-indol-1-yl}pyrimidin-4-yl)oxy]piperidine-1-carbothioate or a salt thereof.
1-(6-{[1-(5-Ethylpyrimidin-2-yl)piperidin-4-yl]oxy}pyrimidin-4-yl)-5-(methylsulfonyl)-2,3-dihydro-1H-indole or a salt thereof.
Dependencies are inferred from the claim text.