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US 8,410,087 B2Granted
Indole compound
AssigneeTakeda Pharmaceutical Company Limited
InventorsTsuneo Yasuma, Osamu Ujikawa, Masahiro Itoh, Kazuko Aoki
Life of this patent
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Abstract
The purpose of the present invention is to provide a glucokinase activator useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of diabetes, obesity and the like. The present invention provides a glucokinase activator containing a compound represented by the formula (I): wherein R1 is a hydrogen atom or a halogen atom; R2 is a group represented by wherein each symbol is defined in the specification, or a salt thereof or a prodrug thereof.
Claims15
A compound represented by the formula (I):
- wherein
- R1 is a hydrogen atom or a halogen atom;
- R2 is a group represented by
- wherein
- R6 is a substituted C1-6 alkyl group;
- and
- R7, R21 and R22 are each independently a hydrogen atom, an optionally substituted hydrocarbon group, a cyano group or an acyl group, or R6 and R7 in combination form an optionally substituted ring;
- W is O or NR8 wherein R8 is a hydrogen atom, an optionally substituted C1-6 alkyl group or an optionally substituted C3-10 cyclo alkyl group;
- R3 is an optionally substituted heterocyclic group or an optionally substituted C6-14 aryl group;
- R10 is an optionally substituted C1-6 alkyl group or an optionally substituted C1-6 alkoxy group;
- and
- R9, and R11 are each independently a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group or an optionally substituted C1-6 alkoxy group,
- or a salt thereof.
10 more elements
Dependencies are inferred from the claim text.