Methods and compositions for prevention or treatment of RSV infection
AssigneeAlnylam Pharmaceuticals, Inc.
InventorsAkshay Vaishnaw, Saraswathy V. Nochur, Sayda Elbashir, Muthiah Manoharan, Rachel Meyers
Life of this patent
Estimating the term…
Abstract
Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose can be formulated for topical or parenteral administration. Topical administration includes administration as a nasal spray, or by inhalation of respirable particles or droplets. The siRNA comprises a sense strand of ALN-RSV01 and an antisense strand of ALN-RSV01.
Claims27
A method of reducing the risk of Respiratory Syncytial Virus (RSV) associated bronchiolitis obliterans syndrome (BOS) in a human lung transplant recipient, comprising administering to said human lung transplant recipient a composition comprising a therapeutically effective amount of ALN-RSV01.
A method of reducing the risk of Respiratory Syncytial Virus (RSV) associated bronchiolitis obliterans syndrome (BOS) in a human lung transplant recipient, comprising administering to said human lung transplant recipient a composition comprising a therapeutically effective amount of ALN-RSV01, wherein the composition is administered daily at 0.6 mg/kg as an aerosol produced by a PARI eFlow® 30L nebulizer.
Dependencies are inferred from the claim text.