Compounds for the treatment or alleviation of edema, and methods for their use
AssigneeIndex Pharmaceuticals AB
InventorsArezou Zargari, Lars-Goran Axelsson, Ann-Kristin Spiik, Nikolai Kouznetsov
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Abstract
Isolated and substantially purified oligonucleotide compounds have been shown to be effective in reducing swelling and edema. Novel methods and substances are presented for the prevention, alleviation or treatment of edema of various aetiology.
Claims28
An oligonucleotide compound comprising a sequence selected from the group consisting of SEQ ID NO 1, SEQ ID NO 2, SEQ ID NO 5, SEQ ID NO 6, SEQ ID NO 7, and SEQ ID NO 10.
A method for the prevention, treatment, and/or alleviation of edema in an individual, comprising administering to the individual an oligonucleotide compound comprising a sequence selected from the group consisting of SEQ ID NO 1, SEQ ID NO 2, SEQ ID NO 3, SEQ ID NO 4, SEQ ID NO 5, SEQ ID NO 6, SEQ ID NO 7, SEQ ID NO 8, SEQ ID NO 9, and SEQ ID NO 10 in a dose effective to achieve one or several of modification of vascular permeability, inhibition of neutrophil migration/activation, inhibition or reduction of eosinophil migration, inhibition or reduction of leukocyte migration, and inhibition or reduction of lymphocyte migration.
An oligonucleotide compound consisting of a sequence selected from the group consisting of SEQ ID NO 1, SEQ ID NO 2, SEQ ID NO 4, SEQ ID NO 5, SEQ ID NO 6, SEQ ID NO 7, SEQ ID NO 8, SEQ ID NO 9, and SEQ ID NO 10.
Dependencies are inferred from the claim text.