Inhibition of versican with siRNA and other molecules
AssigneeBenaroya Research Institute
InventorsThomas N. Wight, Mervyn John Merrilees
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Abstract
The present invention provides methods of treating disease or condition in a subject in need thereof, comprising administering the subject a versican inhibitor in an amount effective to treat the disease or condition. Example diseases or conditions include, but are not limited to, fibrotic disease such as fibrotic lung disease, restenosis such as arterial restenosis, atherosclerosis, cancer, and inflammatory disease. Compounds and compositions for carrying out such a method are also described.
Claims5
A method of treating restenosis in a subject in need thereof, comprising administering said subject a versican inhibitor in an amount effective to inhibit arterial restenosis, wherein said versican inhibitor is an siRNA molecule that inhibits expression of versican isoform V0 and/or versican isoform V1 in said subject;
- wherein said siRNA molecule is directed to the versican G1 region.
Dependencies are inferred from the claim text.