Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
AssigneeGlycoMimetics, Inc.
InventorsJohn L. Magnani, Arun K. Sarkar
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Abstract
Compounds, compositions and methods are provided for treating cancer and inflammatory diseases, and for releasing cells such as stem cells (e.g., bone marrow progenitor cells) into circulating blood and enhancing retention of the cells in the blood. More specifically, heterobifunctional compounds that inhibit both E-selectins and CXCR4 chemokine receptors are described.
Claims33
A heterobifunctional compound for inhibition of E-selectin and the CXCR4 chemokine receptor, comprising E-selectin inhibitor-Linker-CXCR4 chemokine receptor inhibitor, or a physiologically acceptable salt thereof, where the E-selectin inhibitor is not an antibody.
Dependencies are inferred from the claim text.