Oral administration of a calcitonin
AssigneeNovartis AG
InventorYatindra Joshi
Life of this patent
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Abstract
The invention is directed to a method of administering pharmaceutical compositions comprising peptide drugs such as a calcitonin in combination with one or more oral delivery agents, together with an amount of a liquid, and method of treatment of disorders responsive to the action of peptide drugs such as a calcitonin employing such method of administration so as to enhance the oral bioavailability of a calcitonin. The methods of the invention increase the oral absorption and systemic bioavailability of peptide drugs, such as a calcitonin.
Claims14
A method of oral administration of a pharmaceutical composition, comprising a calcitonin, to a human host, prior to the consumption of food, in combination with one or more oral delivery agents, selected from the group consisting of N-(5-chlorosalicyloyl) -8-aminocaprylic acid (5-CNAC), N-(10-[2-hydroxybenzoyl]aminodecanoic acid (SNAD) or N-8-[2-hydroxybenzoyl]amino) caprylic acid (SNAC), and the disodium salts and hydrates and solvates thereof, wherein the pharmaceutical composition is administered together with an amount of about 25 mL to about 100 mL of a liquid.
A method of treating osteoarthritis by administering, twice daily, a therapeutic amount of a calcitonin together with one or more oral delivery agents selected from the group consisting of 5-CNAC, SNAD, SNAC, and the disodium salts and hydrates and solvates thereof, wherein the administration is made with about 50mL of liquid at least 30 minutes prior to the morning meal and evening meal.
A method of treating osteoporosis by administering a therapeutic amount of a calcitonin together with one or more oral delivery agents selected from the group consisting of 5-CNAC, SNAD, SNAC, and the disodium salts and hydrates and solvates thereof, wherein the administration is made with about 50mL of liquid at least 30 minutes prior to the evening meal.
Dependencies are inferred from the claim text.