Compositions and their uses directed to gemin genes
AssigneeIsis Pharmaceuticals, Inc.
InventorsKenneth W. Dobie, Susan M. Freier
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Abstract
Disclosed herein are compounds, compositions and methods for modulating the expression of a Gemin Gene. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
Claims16
A method of modulating expression of a Gemin gene in a cell comprising contacting the cell with an oligomeric compound of from 13 to 30 nucleobases in length and having a nucleobase sequence comprising at least 8 contiguous nucleobases complementary to an equal length portion of nucleobases 1110 to 1183 of SEQ ID NO. 7, and wherein said nucleobase sequence is at least 90% complementary to SEQ ID NO:7 as measured over the entirety of the oligomeric compound, and thereby modulating expression of the Gemin gene.
Dependencies are inferred from the claim text.