System and method for controlling the diameter of a mammilian hybrid coronary bypass graft

A method, comprising:

• providing a tubular structure;
• placing cells in contact with the tubular structure;
• and
• placing the tubular structure and cells in a system that exposes the tubular structure and cells to dynamic conditions in an ex vivo fluid environment effective to promote the cells to exhibit in vivo physiologic function, wherein the system comprises:
• a specimen holder for holding the tubular structure and cells,
• a pressure/flow control system that is fluidly coupled to the specimen holder so as to form a flow loop through which fluid traverse, wherein the pressure/flow control system generates and maintains dynamic fluid pressure and flow conditions within the specimen holder and is capable of independently controlling fluid pressure and flow rate in the specimen holder, and
• a control system for sending control signals to the pressure/flow system.