Compositions, methods and devices for maintaining an organ
AssigneeThe United States of America as represented by the Department of Veteran Affairs
InventorsWaleed Hassanein, Shukri F. Khuri, Michael D. Crittenden, Vladimir Birjinuik
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Abstract
Compositions, methods, systems/devices and media are provided for maintaining a harvested organ in a functioning and viable state prior to implantation. The organ perfusion apparatus includes a preservation chamber for storing the organ during the preservation period. A perfusion circuit is provided having a first line for providing an oxygenated fluid to the organ, and a second line for carrying depleted fluid away from the organ. The perfusion apparatus also includes a device operably associated with the perfusion circuit for maintaining the organ at a substantially normothermic temperature.
Claims18
A perfusion apparatus, comprising
- a chamber assembly for containing a heart,
- a perfusion circuit including a first conduit for providing an oxygenated fluid to the heart, a second conduit for carrying depleted fluid away from the heart, and an afterload device for adjusting back pressure of the fluid,
- a reservoir disposed along the perfusion circuit for containing a portion of the fluid, the reservoir including an inlet for receiving the fluid from the perfusion circuit and outlet for supplying the fluid to the perfusion circuit,
- a pulsatile pump for circulating the fluid through the perfusion circuit,
- an oxygenating device disposed along the perfusion circuit to maintain the heart at physiologic levels of oxygenation, and
- a temperature control device that has a heater and a temperature control sufficient to maintain the fluid at a physiologic temperature,
- wherein the pulsatile pump, oxygenating device, and the temperature control device are adapted to operate with the perfusion circuit to maintain the heart in a functioning and viable state in an ex-vivo environment.
Dependencies are inferred from the claim text.