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US 8,409,837 B2Granted
Crystal structure of glutaminyl cyclase
AssigneeProbiodrug AG
InventorsStephan Schilling, Jens-Ulrich Rahfeld, Birgit Koch, Michael Wermann, Christoph Parthier, David Ruiz-Carillo, Milton T. Stubbs
Life of this patent
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Abstract
A novel crystal structures of human and murine glutaminyl cyclase (QC, EC 2.3.2.5), methods of preparing the crystals, as well as the use of said crystal structures for identifying inhibitors of human and murine glutaminyl cyclase.
Claims8
A crystal comprising human glutaminyl cyclase wherein said human glutaminyl cyclase consists of amino acids 35 to 361 of SEQ ID NO:
- 1 and said crystal is characterized as having space group C121 and unit cell dimensions of +/−5% of a=82.6 Å, b=63.9 Å, c=77.5 Å, α=90°, β=105.7° and γ=90°.
Dependencies are inferred from the claim text.