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US 8,409,824 B2Granted
Methionine sulfoxide antibodies
AssigneeUniversity of Kansas
InventorJackob Moskovitz
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Abstract
Antibodies specific for methionine sulfoxide residues on proteins are provided. The antibodies are prepared using methionine-rich zein proteins, which are oxidized, as antigens.
Claims9
A method for making antibodies that specifically bind to a methionine sulfoxide residue of a polypeptide, the method comprising:
- a) oxidizing a protein comprising at least 23% methionine residues to provide a methionine sulfoxide containing protein;
- b) immunizing an animal with said methionine sulfoxide containing protein or an immunogenic fragment thereof as an antigen, under conditions to elicit an antibody response;
- and
- c) isolating antibodies or antibody-producing cells from the animal which specifically bind to a methionine sulfoxide residue of a polypeptide.
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Dependencies are inferred from the claim text.