sCD40L and placental growth factor (PLGF) used as a biochemical marker combination in cardiovascular diseases
AssigneeSiemens Healthcare Diagnostics Products GmbH
InventorsAndreas M. Zeiher, Christopher Heeschen, Stefanie Dimmeler, Christian Hamm
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Abstract
The invention relates to novel markers of vascular inflammation and combinations thereof as diagnostic and prognostic tools in patients with cardiovascular diseases. The markers also act as tools that facilitate the selection of active ingredients for the treatment of such diseases, and finally act as starting points for the treatment of cardiovascular diseases. Furthermore, the invention relates to the creation of an individual risk profile of negative events that are associated with the progression of arteriosclerosis.
Claims14
A method for determining the prognosis of acute cardiovascular disease comprising:
- (a) obtaining a biological sample to be analyzed;
- (b) measuring the concentration of Placental Growth Factor (PlGF) in the sample;
- (c) measuring the concentration of at least one additional marker selected from PAPP-A, soluble CD40-ligand (sCD40L), troponin T (TnT), MPO, NT-proBNP, VEGF, BNP, PlGF, and IL-10 in the sample;
- (d) comparing the results obtained in (b) and (c) for the biological sample with the respective concentrations in at least one reference sample;
- and
- (e) determining the prognosis of an acute cardiovascular disease.
A method for diagnosing acute cardiovascular disease comprising:
- (a) obtaining a biological sample to be analyzed;
- (b) measuring the concentration of PlGF in the sample;
- (c) measuring the concentration of at least one additional marker selected from PAPP-A, soluble CD40-ligand (sCD40L), troponin T (TnT), MPO, NT-proBNP, VEGF, BNP, PlGF, and IL-10 in the sample;
- ((d) comparing the results obtained in (b) and (c) for the biological sample with the respective concentrations in at least one reference sample;
- and
- (e) diagnosing an acute cardiovascular disease.
Dependencies are inferred from the claim text.