Treatment of cancer using TLR3 agonists
AssigneeInstitut Gustave Roussy
InventorsFabrice Andre, Laurence Zitvogel, Jean-Christophe Sabourin
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Abstract
The present invention relates generally to the fields of genetics and medicine. More specifically, the present invention relates to improved methods of treating cancers using a TLR3 agonist, by assessing the expression of a TLR3 receptor by cancer cells.
Claims13
A method for treating a subject having a melanoma comprising:
- a) determining whether melanoma cells in said subject express a TLR3 receptor comprising SEQ ID NO:
- 2, the expression of a TLR3 receptor comprising SEQ ID NO:
- 2 being indicative of a subject responding to a TLR3 agonist selected from poly I:
- poly C (poly IC), poly A:
- poly U (polyAU), and
- b) administering to said subject whose melanoma cells are determined to express a TLR3 receptor comprising SEQ ID NO:
- 2 a pharmaceutical composition comprising an effective amount of a TLR3 agonist selected from poly I:
- poly C (poly IC) or poly A:
- poly U (poly AU), and a pharmaceutically acceptable carrier.
A method for assessing the response of a subject having melanoma to a treatment using a TLR3 agonist selected from poly I:
- poly C (poly IC) or poly A:
- poly U (polyAU), the method comprising determining whether cancer cells in said subject express a TLR3 receptor comprising SEQ ID NO:
- 2, the expression of a TLR3 receptor comprising SEQ ID NO:
- 2 being indicative of a responder subject, administering a therapeutically effective amount of said -TLR3 agonist to said subject and determining if there has been a reduction in size or spread of said cancer in said subject.
A method for selecting subjects having a melanoma that respond to a treatment using a TLR3 agonist selected from poly I:
- poly C poly IC) or poly A:
- poly U (polyAU), the method comprising determining whether melanoma cells in said subject express a TLR3 receptor comprising SEQ ID NO:
- 2, the expression of a TLR3 receptor comprising SEQ ID NO:
- 2 being indicative of a responder subject, administering a therapeutically effective amount of said TLR3 agonist to said subject if said subject has melanoma cells expressing a TLR3 receptor comprising SEQ ID NO:
- 2 and determining if there has been a reduction in size or spread of said melanoma in said subject.
A method for treating a subject having a melanoma, the method comprising determining whether melanoma cells in said subject express a TLR3 receptor comprising SEQ ID NO:
- 2, the expression of a TLR3 receptor comprising SEQ ID NO:
- 2 being indicative of a subject responding to a TLR3 agonist, and treating said subject whose melanoma cells express a TLR3 receptor comprising SEQ ID NO:
- 2 with a TLR3 agonist selected from poly I:
- poly C (poly IC) or poly A:
- poly U (polyAU).
Dependencies are inferred from the claim text.