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US 8,409,808 B2Granted
Method for detecting risk of progression of low grade cervical dysplasia
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsThomas Ried, Kerstin Heselmeyer-Haddad, Winfried Steinberg, Gert Auer, Sonia Andersson, Catharina Larsson
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Abstract
The invention provides methods for identifying conditions of low grade cervical dysplasia and assessing the progressive potential of individual lesions to develop into high grade cervical dysplasia and cervical squamous cell cancer as well as cervical adenocarcinoma.
Claims14
A method for assessing the risk of developing high grade cervical dysplasia or cancer in a patient diagnosed as having low grade cervical dysplasia or no cervical dysplasia, comprising:
- i) obtaining a cervical sample from the patient;
- ii) detecting any genomic amplification of chromosome 3q in the cervical sample;
- and
- iii) identifying the patient as at risk of developing high grade cervical dysplasia or cancer when genomic amplification of chromosome 3q is detected in the cervical sample;
- or identifying the patient as not at risk of developing high grade cervical dysplasia or cancer, and/or as having a condition of maintenance or regression of low grade cervical dysplasia, when genomic amplification of chromosome 3q is not detected in the cervical sample.
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