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US 8,409,616 B2Granted
Extended release opioid abuse deterrent compositions and methods of making same
AssigneeAcura Pharmaceuticals, Inc.
InventorsVijai Kumar, David Dixon, Divya Tewari, Dilip B. Wadgaonkar
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Abstract
This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix.
Claims17
A therapeutic pharmaceutical composition comprising:
- a mixture including
- (a) a water soluble drug susceptible to abuse at about 0.5 to about 25 percent by weight;
- (b) gel-forming polymer at about 3 to about 40 percent by weight;
- (c) a disintegrant at about 2 to 25 percent by weight wherein the disintegrant is selected from the group consisting of crospovidone, sodium starch glycolate, and croscarmellose sodium;
- and
- (d) sorbitan monoester at about 1 to 10 percent by weight.
3 more elements
A therapeutic pharmaceutical composition comprising:
- a mixture including
- (a) a water soluble drug susceptible to abuse;
- (b) a gel-forming polymer in an amount of about 3 to about 40 wt %;
- (c) a disintegrant;
- and
- (d) a surfactant;
- wherein the disintegrant is present in an amount sufficient to cause the pharmaceutical composition to exhibit an immediate release profile.
4 more elements
Dependencies are inferred from the claim text.