Gastric retained gabapentin dosage form

A method of treating psychiatric disorders comprising administering a gastric retained dosage form comprising a therapeutically effective amount of gabapentin or a pharmaceutically acceptable salt thereof to a mammal in need of such treatment, wherein the dosage form comprises a matrix and the gabapentin is dispersed in the matrix, and

• wherein upon ingestion of the dosage form the gabapentin is released from the matrix into the upper gastrointestinal tract over about 5-12 hours at a rate sufficient to achieve a lower maximum plasma concentration (Cmax) than that provided by an immediate release dosage form comprising an equal amount of gabapentin, and bioavailability of the gabapentin is at least 80% of that provided by the immediate release dosage form comprising an equal amount of gabapentin as measured b the area under the plasma concentration-time curve, AUCinf.

A method of treating movement disorders comprising administering a gastric retained dosage form comprising a therapeutically effective amount of gabapentin or a pharmaceutically acceptable salt thereof to a mammal in need of such treatment, wherein the dosage form comprises a matrix and the gabapentin is dispersed in the matrix, and

• wherein upon ingestion of the dosage form the gabapentin is released from the matrix into the upper gastrointestinal tract over about 5-12 hours at a rate sufficient to achieve a lower maximum plasma concentration (Cmax) than that provided by an immediate release dosage form comprising an equal amount of gabapentin, and bioavailability of gabapentin is at least 80% of that provided by the immediate release dosage form comprising an equal amount of gabapentin as measured by the area under the plasma concentration-time curve, AUCinf.

A method for administering a therapeutically effective amount of gabapentin to a mammal in need thereof, the method comprising

• administering gabapentin or a pharmaceutically acceptable salt thereof in a gastric retained dosage form comprising a matrix, wherein the gabapentin is dispersed in the matrix, and
• wherein the mammal is being treated for movement disorders, psychiatric disorders, or wherein the mammal is receiving prophylactic treatment for migraine headaches, and
• wherein upon ingestion of the dosage form the gabapentin is released from the matrix into the upper gastrointestinal tract over about 5-12 hours at a rate sufficient to achieve a lower maximum plasma concentration (Cmax) than that provided by an immediate release dosage form comprising an equal amount of gabapentin, and bioavailability of the gabapentin is at least 80% of that provided by the immediate release dosage form comprising an equal amount of gabapentin as measured by the area under the plasma concentration-time curve, AUCinf.