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US 8,409,603 B2Granted
Compositions and methods for tissue engineering, tissue regeneration and wound healing
AssigneesUniversity of South Carolina, Medical University of South Carolina
InventorsRobert G. Gourdie, Jay D. Potts
Life of this patent
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Abstract
In accordance with certain embodiments of the present disclosure, a kit is described. The kit includes primed living cells joined to and at least partially within a three-dimensional hydrogel structure and an isolated polypeptide having the carboxy-terminal amino acid sequence of an alpha Connexin, or a conservative variant thereof, wherein the polypeptide does not include the full length alpha Connexin protein.
Claims7
A method of promoting healing following tissue injury in a subject, comprising:
- administering to the subject's injury a toroid structure comprising primed living bone marrow stem cells which are joined to and at least partially within a three-dimensional collagen structure and an isolated polypeptide comprising the carboxy-terminal amino acid sequence of an alpha Connexin, wherein the carboxy-terminal amino acid sequence is capable of inhibiting gap junction formation.
Dependencies are inferred from the claim text.