Methods for prevention and/or treatment of capsular contracture
AssigneeJ&E Solutions, LLC
InventorsJeanne V. Friedman, Elsa M. Raskin
Life of this patent
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Abstract
Methods for prevention or treatment of capsular contracture following surgical implants and other fibrosis related conditions comprising applying a topical composition comprising a pharmaceutically acceptable keratolytic, a pharmaceutically acceptable protein denaturant, a hydrating agent, and combinations thereof are disclosed.
Claims19
A method of treating capsular contracture, comprising topically applying to a human on an affected area which has developed or is at risk of developing capsular contracture, a topical composition containing:
- an amount of a pharmaceutically acceptable and topically active ingredient effective to treat said capsular contracture, said active ingredient comprises:
- a keratolytic comprising salicylic acid, and
- a protein denaturant comprising urea.
A method of treating capsular contracture, comprising topically applying to a human on a post-surgical implant area which has developed or is at risk of developing capsular contracture a topical composition comprising a protein denaturant comprising from about 5 to about 20% (w/w) urea together with a keratolytic comprising salicylic acid.
A method of treating capsular contracture, comprising:
- preparing a topical composition comprising from about 5 to about 20% (w/w) urea together with salicylic acid as a stable, uniform water-washable ointment of a non-aqueous emulsion,
- topically applying the topical composition at least once daily to a human on a post-surgical implant area which has developed or is at risk of developing capsular contracture,
- massaging the post-surgical implant area, and
- applying heat to the post-surgical implant area prior to applying the topical composition.
Dependencies are inferred from the claim text.