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US 8,409,587 B2Granted
Immunogenic composition
AssigneeGlaxosmithkline Biologicals SA
InventorsYves Mayeresse, Jean Stephenne
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Abstract
The present invention relates to immunogenic compositions comprising a dried solid or highly viscous liquid formulation of inactivated polio virus (IPV) and a stabilizing agent wherein the IPV retains its antigenicity and/or immunogenicity. Methods of producing a dried formulation of IPV which retains its antigenicity/immunogenicity are described.
Claims13
An immunogenic composition comprising:
- (a) inactivated polio virus (IPV) comprising type 1, type 2, and type 3 polio virus,
- (b) a capsular polysaccharide or oligosaccharide antigen from Haemophilus influenzae b, and
- (c) a stabilizing agent,
- all formulated as a dried composition, which after reconstitution is capable of generating an immune response against polio virus,
- wherein the antigenicity of type 1, type 2, and type 3 polio virus is retained at a level of at least 40% of the antigenicity of a reference sample which has not been formulated as a dried composition, and
- wherein the stabilizing agent comprises a glass-forming polyol selected from the group consisting of:
- trehalose, sucrose, sorbitol, raffinose, mannitol, lactose, lactitol, or palatinit.
4 more elements
Dependencies are inferred from the claim text.