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US 8,409,586 B2Granted
Stable liquid formulation of human growth hormone
AssigneeDaewoong Co., Ltd.
InventorsSun hee Kim, Yo kyung Chung, Jae young Chang, Sang kil Lee, Min suk Lee, Seung kook Park
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Abstract
Disclosed herein is a stable liquid formulation comprising human growth hormone; L-lysine, L-arginine or polyethylene glycol 300; and poly(oxyethylene) poly(oxypropylene) copolymer, polyethylene glycol-15 polyoxystearate or polyethylene glycol-35 castor oil.
Claims4
A liquid formulation comprising human growth hormone;
- L-lysine or L-arginine;
- and poly(oxyethylene) poly(oxypropylene) copolymer 188, polyethylene glycol-15 polyoxystearate or polyethylene glycol-35 castor oil,
- wherein the human growth hormone is present in an amount ranging from 2.5 to 5.5 mg/ml;
- the L-lysine or L-arginine in an amount ranging from 0.02 to 0.5% (w/v) per mg of the human growth hormone;
- and the poly(oxyethylene) poly(oxypropylene) copolymer 188, polyethylene glycol-15 polyoxystearate or polyethylene glycol-35 castor oil in an amount ranging from 0.1 to 0.5% (w/v).
2 more elements
Dependencies are inferred from the claim text.