Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers
AssigneeAC Immune SA
InventorsPierre-Francois Tosi, Claudie Madoulet, Claude Nicolau, David T. Hickman
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Abstract
The invention relates to an immunogenic composition which comprises, firstly, a carrier and, secondly, as antigenic structure, conjugates comprising all or part of the amino acid sequences of at least one peptide derived from an extracellular loop of the P-170 protein, each peptide being combined with several molecules of fatty acid containing a carbon chain of between C12 and C24 so as to allow, under suitable administration conditions, the induction of anti-P-170 antibodies. The invention relates to said composition for defining means for treating multidrug resistances.
Claims19
A method of inducing production of antibodies in a patient in need thereof wherein the patient exhibits multidrug resistance comprising administering to said patient a composition comprising:
- conjugates comprising at least one peptide consisting of between 10 and 25 amino acid residues, wherein the at least one peptide
- consists of SEQ ID NO:
- 5 or SEQ ID NO:
- 6,
- comprises SEQ ID NO:
- 5 or SEQ ID NO:
- 6, or
- consist of at least 10 consecutive amino acids of SEQ ID NO:
- 5 or SEQ ID NO:
- 6, each of said at least one peptides being combined with at least four molecules of fatty acid containing a carbon chain of between C12 and C24, and
- virosomes or liposomes.
A method of inducing production of antibodies comprising administering to a patient in need thereof composition comprising:
- conjugates comprising at least one peptide consisting of between 10 and 25 amino acid residues, wherein the at least one peptide
- consists of SEQ ID NO:
- 5 or SEQ ID NO:
- 6,
- comprises SEQ ID NO:
- 5 or SEQ ID NO:
- 6, or
- consist of at least 10 consecutive amino acids of SEQ ID NO:
- 5 or SEQ ID NO:
- 6, each of said at least one peptide being combined with at least four molecules of fatty acid containing a carbon chain of between C12 and C24, and
- virosomes or liposomes.
Dependencies are inferred from the claim text.