Monoclonal antibodies with enhanced ADCC function
AssigneeLaboratoire Francais Du Fractionnement Et Des Biotechnologies
InventorsRoland Beliard, Dominique Bourel, Arnaud Glacet, Christophe De Romeuf, Nicolas Bihoreau, Emmanuel Nony
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Abstract
The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fcy receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing Rhesus isoimmunization in Rh negative persons, in particular for haemolytic disease in a new-born baby of for uses such as idiopathic thrombocytopenic purpura (ITP).
Claims19
A monoclonal antibody composition comprising purified monoclonal antibodies having on the Fcγ glycosylation site (Asn 297, EU numbering) bi-antennary glycan structures,
- wherein said glycan structures of the purified monoclonal antibodies have a fucose content less than 30%.
A monoclonal antibody composition comprising purified monoclonal antibodies having on the Fcγ glycosylation site (Asn 297, EU numbering) bi-antennary glycan structures,
- wherein said glycan structures of the purified monoclonal antibodies have a content less than 30% for the G0F+G1F forms.
Dependencies are inferred from the claim text.