Methods and compositions for treatment of ion imbalances
AssigneeRelypsa, Inc.
InventorsDominique Charmot, Han-Ting Chang, Mingjun Liu, Futian Liu, Gerrit Klaerner
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Abstract
The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
Claims16
A method of removing sodium from an animal subject comprising administering to an animal subject in need thereof an effective amount of a core-shell composition comprising a cation exchange core and a semi-permeable shell wherein the semi-permeable shell comprises a polymer containing at least one of a poly-11 trimethylammonioundecylmethacrylate polymer, or a 11-dimethyl-aminodecylmethacrylate/laurylmethacrylate copolymer, wherein said semi-permeable shell has a high permeability to sodium in the duodenum where the shell is in a hydrated state at neutral pH and has a reduced permeability to sodium in the cecum and colon where it is in a collapsed-impermeable state when the pH is 5 or 6, whereby as the core-shell composition passes from the duodenum to the cecum and colon its permeability to sodium decreases.
Dependencies are inferred from the claim text.