Solid dispersion formulations and methods of use thereof
AssigneeZalicus Pharmaceuticals Ltd.
InventorsMahesh V. Padval, Jeff T. Gautschi, Daniel T. Smithey, Marshall D. Crew, Abizer Harianawala
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Abstract
The present invention relates to formulations and methods for increasing the bioavailability of 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one, 1-(3,3-diphenylpropanoyl)piperazine, or a salt thereof. In particular, the formulation can include one or more pharmaceutically acceptable matrix polymers to form a solid dispersion, e.g., a spray dried dispersion or a hot melt extrusion.
Claims4
A pharmaceutical composition in unit dosage form for oral administration comprising a solid dispersion of from about 20 mg to about 250 mg of substantially amorphous 1-(4-benzhydrylpiperazine-1-yl)-3,3-diphenylpropan-1-one in a matrix polymer, wherein said matrix polymer comprises a member selected from the group consisting of a cellulose derivative, a polyacrylate, a polyvinyl pyrrolidone, a polyvinyl acetate, or a copolymer of a polyvinyl pyrrolidone and a polyvinyl acetate and wherein the percentage loading of said 1-(4-benzhydrylpiperazine-1-yl)-3,3-diphenylpropan-1-one in said solid dispersion is from about 10% to about 80% (w/w).
Dependencies are inferred from the claim text.