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US 8,409,523 B2Granted
Assay device comprising serial reaction zones
AssigneeAmic AB
InventorsIb Mendel-Hartvig, Gerd Rundström, Per Ove Öhman
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AssigneeAmic AB
InventorsIb Mendel-Hartvig, Gerd Rundström, Per Ove Öhman
Estimating the term…
An analysis device having at least one sample addition zone, at least one sink, and at least one flow path connecting the at least one sample addition zone and the at least one sink. The at least one flow path includes projections substantially vertical to the surface of the substrate and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such that lateral capillary flow of a liquid sample is achieved. The device includes at least two reaction zones in series, wherein each reaction zone is adapted to facilitating measurement of a response originating from one and the same analyte, and wherein the reaction zones are positioned to allow calculation of the concentration of at least one analyte. Advantages include that a more accurate value can be calculated, variations are reduced, and an estimation of the uncertainty of the response can be calculated.
An analysis device comprising a non-porous substrate having at least one sample addition zone, at least one sink, and at least one flow path connecting the at least one sample addition zone and the at least one sink, wherein the at least one flow path comprises projections substantially vertical to the surface of said substrate and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such that lateral capillary flow of a liquid sample is achieved, and at least two reaction zones in series, wherein each reaction zone is adapted to facilitating measurement of a response originating from one and the same analyte, and wherein the reaction zones are positioned to allow calculation of the concentration of at least one analyte and wherein the reaction zone closet to the at least one sample addition zone is defined by an area which is different from the are of any one of the other reaction zones.
Dependencies are inferred from the claim text.