Composition used for increasing calmodulin and method thereof

#(a) Field of the Invention

#The present invention relates to a composition used for increasing calmodulin and a method thereof, and more particularly to a composition which can irradiate an far-infrared ray with a specific wavelength to induce the expression of calmodulin and a method thereof.

#(b) Description of the Prior Art

#FIG. 1 is a curve diagram of the far-infrared emissivity of the far-infrared releasing substance according to the present invention;

#FIG. 2 is a flow chart of a method for increasing calmodulin according to the present invention;

#FIG. 3 shows the influence of the release time of far-infrared rays on the calmodulin contents in RAW 264.7 cells incubated without addition of LPS according to the present invention, wherein FIG. 3A is a photograph showing the calmodulin contents detected by Western blotting, and FIG. 3B is a bar chart showing the incubation time vs. the calmodulin contents;

#The present invention will be further described in detail with reference to the following preferred embodiments and the accompanying drawings.

#The composition used for increasing calmodulin according to the present invention comprises a far-infrared releasing substance. Far-infrared rays released by the far-infrared releasing substance can enhance intracellular production of calmodulin. The far-infrared releasing substance may be a ceramic mineral and comprises 80-99.9 wt % of an oxide mineral, and the balance (0.1-20 wt %) may comprise such as titanium boride, zinc hydroxide or carbide. Besides, the oxide mineral mainly comprises 60-95 wt % of 1 alumina, and further comprises titanium dioxide, titanium boride, magnesium oxide, silicon oxide, ferric oxide or zinc oxide. In a preferred embodiment of the present invention, the far-infrared releasing substance consists of 60-95 wt % of alumina, 1-20 wt % of ferric oxide, 1-10 wt % of magnesium oxide, 1-10 wt % of zinc oxide, and 0.1-20 wt % of calcium carbonate.

#Furthermore, the far-infrared releasing substance can irradiate a far-infrared ray at room temperature, which is measured by an FIR spectrometer using a black body as a standard to obtain the emissivity up to greater than 0.9 at a wavelength of 6-14 μm, and the emissivity can further be greater than 0.95 at a wavelength of 7-14 μm. As illustrated in FIG. 1, the average emissivity can be almost high up to 0.98. The cells that can be induced in the present invention may comprise fibroblasts, endothelial cells, macrophages, nerve cells, or the like. The composition may be in a lump, granular, powdered or thin-film form. Additionally, the composition used for increasing calmodulin according to the present invention may comprise a matrix or filler. The matrix or filler may comprise materials such as metal, glass, ceramics or polymers. The present invention can be fully applied to a living environment by mixing the far-infrared releasing substance into the matrix or filler. For example, if the far-infrared releasing substance is blended into the window glass of a building, the subject who lives in the building will receive far-infrared rays released by the far-infrared releasing substance, so as to achieve the purpose of increasing calmodulin.