Systems, methods, and compositions for achieving closure of suture sites

An apparatus comprising:

• a first component sized and configured to place a suture loop through tissue to join tissue and to tie the suture loop to form a suture closure, and
• a second component sized and configured to separately contain two separate solutions and to discharge the solutions together as a two-component liquid closure material;
• the two-part liquid closure material comprising
• a first solution containing an electrophilic component comprising a hydrophilic, biocompatible polymer that is electrophilically derivatized with a functionality of at least three and
• a second solution containing a nucleophilic component comprising recombinant or natural serum albumin in a concentration of 25% or less and a buffer component adjacent the suture closure,
• the liquid closure material cross-linking after discharge to form a solid closure adjacent the suture knot having cohesive and tissue adhesive strength to impede blood flow without clot formation.