Sequential introduction of skin penetrators

A method of introducing skin penetrators into skin, comprising:

• providing a device which comprises:
• a puncturing part for piercing the skin, wherein the puncturing part moves from an initial position to a puncturing position in which the puncturing part pierces the skin to define an opening therein, and from the puncturing position to a post-puncturing position in which the puncturing part is removed from the opening,
• an indwelling part, wherein the indwelling part moves from an initial position to an indwelling position in which the indwelling part is introduced into the skin through the opening generated by the puncturing part,
• a housing in or on which the puncturing part and the indwelling part are arranged, wherein in the initial position a distal end of the indwelling part is disposed above a bottom surface of the housing, and in the indwelling position the distal end of the indwelling part is disposed below the bottom surface of the housing,
• a guide associated with the device, wherein the indwelling part is moved in or onto the guide after the puncturing part is moved in or onto the guide, and
• a drive device adapted to drive the puncturing part into the skin;
• applying the bottom surface of the device to the skin;
• and
• operating the device to move the puncturing part via the drive device from the initial position to the puncturing position such that the puncturing part pierces the skin to define the opening and from the puncturing position to the post-puncturing position thereby removing the puncturing part from the opening, and
• moving the indwelling part relative to the puncturing part from the initial position to the indwelling position, wherein respective movements of the puncturing part and indwelling part are substantially spaced-apart from each other throughout their respective movements into the skin.