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US 8,409,126 B2Granted
Selective cytopheresis devices and related methods thereof
AssigneesThe Regents of the University of Michigan, CytoPherx, Inc.
InventorsH. David Humes, Deborah Buffington
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Abstract
The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
Claims43
A method for processing cells contained within a body fluid from a subject with acute renal failure, wherein the cells are primed or activated leukocytes, the method comprising:
- (a) sequestering extracorporeally the cells from the subject;
- and
- (b) treating the cells sequestered during step (a) with a calcium chelator to inhibit release of a pro-inflammatory substance from the cells or to deactivate the cells.
A method of treating a subject with acute renal failure, the method comprising:
- (a) sequestering extracorporeally primed or activated leukocytes in a body fluid from the subject;
- and
- (b) treating the leukocytes sequestered during step (a) with a calcium chelator to inhibit release of a pro-inflammatory substance from the leukocytes or to deactivate the leukocytes.
Dependencies are inferred from the claim text.