Xanthones, thioxanthones and acridinones as DNA-PK inhibitors

A compound having a formula

• or a pharmaceutically acceptable salt thereof,
• wherein m is an integer 0 through 3;
• X is O, S(O)0-2, or NRa;
• Z, independently, is CRb or N;
• R1, independently, is selected from the group consisting of halo, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, N(Rd)2, ORd, carboxy, wherein the carboxy is not carboxyl, nitro, OC1-3alkyleneN(Rd)2, N(Rd)—C1-3alkyleneN(Rd)2, OC1-3alkyleneC(═O)ORd, O(C1-3alkylene) OP(═O)(ORd)2, O(C1-3alkylene)OP(═O)(ONa)2, OP(═O)—(ORd)2, OP(═O)(ONa)2, cyano, aldehyde, carboxamide, thiocarboxamide, acyl, mercapto, sulfonyl, trifluoromethyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl;
• or
• two R1 groups are taken together with the atoms to which each is attached to form a 5-, 6-, or 7-membered ring, wherein 1 or 2 carbon atoms of R1 optionally is a heteroatom selected from the group consisting of O, N, and S, said ring optionally substituted with one or more ═O, ═S, ═NH, ORd, N(Rd)2, carboxyl, carboxy, alkyl, aryl, substituted aryl, heteroaryl, or substituted hetercaryl, said heteroatom optionally substituted with a group selected from the group consisting of aryl, substituted aryl, alkyl, substituted alkyl, and acyl;
• Ra is selected from the group consisting of hydro, C1-4alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, C1-3alkylenearyl, C1-3alkyleneheteroaryl, C1-3alkyleneheterocycloalkyl, C1-4alkylene-N(Rd)2, C1-4alkyleneORd, C1-4alkyleneC(═O)ORd, C(═O)Rd, C(═O)N(Rd)2, C(═O)ORd, C(═O)SRd, C(═S)N(Rd)2, SO2Rd, SO2N(Rd)2, C(═O)NRdC1-4alkyleneORd, C(═O)NRdC1-4alkyleneheterocycloalkyl, C(═O)C1-4alkylenearyl, C(═O)C1-4alkyleneheteroaryl, C1-4alkyleneC(═O)C1-4alkylenearyl, C1-4alkyleneC(═O)C1-4alkyleneheteroaryl, C1-4alkylene-C(═O) heterocycloalkyl, C1-4alkyleneNRdC(═O)Rd, C1-4 alkyleneOC1-4alkyleneORd, C1-4alkyleneOC1-4alkyleneC(═O)ORd, and C1-4alkyleneC(═O)N(Rd)2;
• Rb, independently, is selected from the group consisting of hydro, alkyl, halo, aldehyde, ORd, O(C1-3alkylene)OP(═O)(ORd)2, O(C1-3alkylene)OP(═O)(ONa)2, OP(═O)(ORd)2, OP(═O)(ONa)2, nitro, N(Rd)2, carboxyl, carboxy, sulfonamido, sulfamyl, and sulfo;
• and
• Rd, independently, is selected from the group consisting of hydro, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, C1-3alkylenearyl, substituted aryl, heteroaryl, and substituted heteroaryl.