Gated voltammetry
AssigneeBayer HealthCare LLC
InventorHuan-Ping Wu
Life of this patent
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Abstract
A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated voltammetric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, a single set of calibration constants, under-fill, and changes in the active ionizing agent content of the sensor strip.
Claims41
In an electrochemical method for determining the concentration of an analyte in a sample, where the method includes applying an input signal to a sensor strip so the analyte undergoes a redox reaction to generate an electric current that is measured and correlated with the concentration of the analyte in the sample,
- the sensor strip including electrodes and reagents, where the reagents include an oxidoreductase and react with and transfer electrons from the analyte to the electrodes;
- the improvement comprising applying a gated voltammetric pulse sequence to the sample comprising at least two duty cycles, where each of the duty cycles includes an excitation and a relaxation, the relaxation is from 0.1 to 3 seconds, and the relaxation includes a current reduction to one-half or less of the current flow at the excitation maxima.
A voltammetric method for determining the concentration of an analyte in a sample, comprising:
- applying a pulse sequence to the sample, the pulse sequence having at least two duty cycles,
- where each of the duty cycles includes an excitation and a relaxation,
- where the excitation includes a potential varied with time, and
- where the relaxation is from 0.1 to 3 seconds and includes a current reduction to at least one-half the current flow at the excitation maxima;
- measuring resulting currents from at least one of the excitations including the potential varied with time;
- and
- determining the concentration of the analyte in the sample from at least one of the resulting currents.
Dependencies are inferred from the claim text.