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US 8,399,201 B2Granted
Polypeptide complex of TRPM8 and calmodulin and its uses thereof
AssigneeJanssen Pharmaceutica NV
InventorsNing Qin, Christopher M. Flores
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Abstract
The present invention discovered that a mammalian TRPM8 binds to calmodulin. The present invention provides a polypeptide complex comprising a cold-menthol receptor (TRPM8) or an active fragment or derivative of TRPM8 and a calmodulin or an active fragment or derivative of calmodulin, and the uses of the polypeptide complex.
Claims32
An isolated polypeptide complex comprising 1) a polypeptide comprising TRPM8 or an active fragment of TRPM8 comprising SEQ ID NO:
- 9 interacting with 2) calmodulin or an active fragment of calmodulin comprising SEQ ID NO:
- 1.
An isolated active fragment of TRPM8 consisting of the amino acid sequence of SEQ ID NO:
- 9.
Dependencies are inferred from the claim text.