Haemophilus influenzae type IV pili
AssigneeNationwide Children's Hospital, Inc.
InventorsLauren O. Bakaletz, Robert S. Munson, Jr.
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Abstract
The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type pili from nontypeable H. influenzae (NTHi) and from H. influenzae strains a, b, c, e and f. The invention provides isolated H. influenzae pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to H. influenzae and methods of treating and preventing H. influenzae related pathological conditions.
Claims15
A fusion protein comprising a polypeptide comprising an amino acid sequence of any one of SEQ ID NO:
- 2, SEQ ID NO:
- 4, SEQ ID NO:
- 6, SEQ ID NO:
- 8, SEQ ID NO:
- 10, SEQ ID NO:
- 12, SEQ ID NO:
- 14, SEQ ID NO:
- 16, SEQ ID NO:
- 18, SEQ ID NO:
- 20, SEQ ID NO:
- 22, SEQ ID NO:
- 26, SEQ ID NO:
- 34, SEQ ID NO:
- 36, SEQ ID NO:
- 38, SEQ ID NO:
- 40, SEQ ID NO:
- 42, or SEQ ID NO:
- 44.
A fusion protein comprising a peptide fragment of the amino acid sequence of any one of SEQ ID NO:
- 2, SEQ ID NO:
- 4, SEQ ID NO:
- 6, SEQ ID NO:
- 8, SEQ ID NO:
- 10, SEQ ID NO:
- 12, SEQ ID NO:
- 14, SEQ ID NO:
- 16, SEQ ID NO:
- 18, SEQ ID NO:
- 20, SEQ ID NO:
- 22, SEQ ID NO:
- 26, SEQ ID NO:
- 34, SEQ ID NO:
- 36, SEQ ID NO:
- 38, SEQ ID NO:
- 40, SEQ ID NO:
- 42, or SEQ ID NO:
- 44, wherein the peptide fragment elicits an immune response to H. influenzae pilin polypeptide or wherein the peptide fragment inhibits H. influenzae cellular adherence.
A fusion protein comprising a peptide fragment of the amino acid sequence of SEQ ID NO:
- 2, wherein the peptide fragment comprises amino acids 35 through 68 of SEQ ID NO:
- 2.
A fusion protein comprising a peptide fragment of the amino acid sequence of SEQ ID NO:
- 2, wherein the peptide fragment comprises amino acids 103 through 137 of SEQ ID NO:
- 2.
The fusion protein comprising a peptide fragment of the amino acid sequence of SEQ ID NO:
- 2, wherein the peptide fragment comprises amino acids 21 through 35 of SEQ ID NO:
- 2.
A fusion protein comprising a peptide fragment of the amino acid sequence of SEQ ID NO:
- 2, wherein the peptide fragment elicits an immune response to H. influenzae pilin polypeptide or wherein the peptide fragment inhibits H. influenzae cellular adherence.
Dependencies are inferred from the claim text.