Compositions and methods for the treatment of viral hepatitis
AssigneeHepC Biotechnológiai Kutató és Fejlesztö Kft.
InventorsTibor Bakács, Imre Kövesdi, Vilmos Palya
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Abstract
The present invention discloses a novel apathogenic viral strain useful in the treatment of viral hepatitis infections. The preferred viral strain of Infectious Bursal Disease Virus (IBDV) is specifically characterized in terms of structure and biological activities. The invention also provides recombinant IBDV viral vectors for the inclusion of exogenous nucleic acid sequences enhancing the viral replication inhibitory effect of the virus of the invention. Preferably, the viral vector comprises a nucleic acid sequence encoding a cytokine. A method of treating viral hepatitis in a host comprising administering an anti-hepatitis effective amount of the IBDV strain of the present invention also provided.
Claims7
A composition selected from the group consisting of (i) an Infectious Bursal Disease Virus (IBDV) strain which can be grown in the HepG2 human liver cell line without causing detrimental effects to the cells, said strain comprising the RNA nucleotide sequences SEQ ID NO:1 and SEQ ID NO:2;
- (ii) a recombinant IBDV vector comprising the nucleotide sequence of the IBDV strain;
- and
- (iii) a pharmaceutical preparation comprising the IBDV strain or the IBDV vector, and a suitable carrier or excipient.
Dependencies are inferred from the claim text.