Polysaccharide gel formulation having multi-stage bioactive agent delivery
AssigneeAllergan, Inc.
InventorsDimitrios Stroumpoulis, Dustin B. Leslie, Christopher S. Mudd, Ahmet Tezel
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Abstract
Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide.
Claims6
A soft tissue augmentation system comprising chondroitin sulfate A (CSA)-containing, alginate-coated chitosan particles dispersed in a cross-linked hyaluronic acid matrix wherein the final concentration of CSA is between about 1 mg/mL and about 10 mg/mL.
A soft tissue augmentation system comprising chondroitin sulfate A (CSA)-containing, alginate-coated chitosan particles dispersed in a cross-linked hyaluronic acid matrix wherein the final concentration of CSA is between about 1 mg/mL and about 10 mg/mL and wherein said HA matrix further contains from about 1 mg/mL to about 10 mg/mL of tannic acid.
A soft tissue augmentation system comprising tannic acid-containing, alginate-coated chitosan particles dispersed in a cross-linked hyaluronic acid matrix wherein the final concentration of tannic acid is between about 0.1 mg/mL and about 2 mg/mL.
Dependencies are inferred from the claim text.