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US 8,394,630 B2Granted
Producing a mammalian pluripotent cell population from mammalian blastomere-like stem cells (BLSCs)
AssigneeStemBios Technologies, Inc.
InventorsJames Wang, Yun Yen
Life of this patent
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Abstract
Disclosed are novel stem cells of non-embryonic origins and the uses thereof.
Claims12
A method of making a mammalian pluripotent cell population comprising obtaining a plurality of mammalian blastomere-like stem cells (BLSCs);
- culturing the BLSCs in a medium containing retinoic acid (RA) or transforming growth factor beta (TGF-I3) for a sufficient period of time to produce a pluripotent cell population that is 1-15 micrometers in size and expresses mRNA encoding GAPDH or beta-actin, and
- identifying and isolating the mammalian pluripotent cell population, wherein the pluripotent cell population differentiates into cells derived from ectoderm, mesoderm and endoderm germ layers.
A composition comprising cultured mammalian cells that (1) are pluripotent, (2) are 1-15 micrometers in size, and (3) express the mRNA encoding GAPDH or beta-actin, and wherein the plurality of cultured cells are CD10+, CD90+, CD105+ and CXCR4+.
Dependencies are inferred from the claim text.