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US 8,394,411 B2Granted
Papillomavirus pseudoviruses for detection and therapy of tumors
AssigneeThe United States of America as represented by the Secretary, Dept. of Health and Human Services National Institutes of Health
InventorsJeff Roberts, Douglas R. Lowy, John T. Schiller
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Abstract
Disclosed herein are methods of detecting tumors, monitoring cancer therapy, and selectively inhibiting the proliferation and/or killing of cancer cells utilizing a papilloma pseudovirus or a papilloma virus-like particle (VLP).
Claims9
A method of inhibiting the proliferation of cancer cells and/or killing cancer cells comprising
- administering to a subject having cancer a composition that comprises a therapeutic agent formulated with a papilloma pseudovirus or a papilloma VLP, wherein the therapeutic agent is selected from the group consisting of:
- a) a gene selected from the group consisting of:
- i) a tumor suppressor gene;
- ii) a pro-apototic gene;
- iii) a gene encoding a cytokine, a lymphokine, a monokine, a growth factor, an enzyme or a hormone;
- iv) an immunomodulatory gene;
- v) a gene encoding a cytotoxic polypeptide;
- and,
- vi) a suicide gene;
- b) a cytotoxin;
- c) a radionuclide;
- d) a pro-drug;
- and
- e) a therapeutic nucleic acid.
11 more elements
Dependencies are inferred from the claim text.