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US 8,389,757 B2Granted
Process for preparing teriflunomide
AssigneeAlembic Limited
InventorsKeshav Deo, Samir Patel, Snehal Dhol, Sunil Sanghani, Vishal Ray
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Abstract
The present invention relates to a process for preparing Teriflunomide of formula (I).
Claims8
A process for preparation of Teriflunomide (I)
- comprising steps of:
- reacting ethyl cyanoacetate (II)
- with an acetylating agent in the presence of a base and optionally in the presence of a solvent to obtain Ethyl-2-cyano-3-hydroxy-but-2-enoate (III)
- reacting Ethyl-2-cyano-3-hydroxy-but-2-enoate (III) with 4-trifluoromethyl aniline (IV)
- optionally in the presence of solvent to give Teriflunomide (I).
2 more elements
Dependencies are inferred from the claim text.