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AssigneeDendreon Corporation
InventorsSateesh K. Natarajan, Ofir Moreno, Thomas J. Graddis, David F. Duncan, Reiner Laus, Feng Chen
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Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.
A method for decreasing the viability of a Trp-p8 expressing cell, said method comprising the step of contacting said cell with a compound of Formula IV
A method for inducing apoptosis and/or necrosis in a cell expressing Trp-p8, said method comprising the step of administering to said cell a compound of Formula IV
A method for treating a disease associated with Trp-p8 expression, said method comprising the step of administering to a mammal an efficacious amount of a composition comprising a compound having the formula:
Dependencies are inferred from the claim text.