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US 8,389,709 B2Granted
Compositions and methods for treating tumors, fibrosis, and pulmonary alveolar proteinosis
AssigneeTechnion Research & Development Foundation Limited
InventorGera Neufeld
Life of this patent
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Abstract
The present disclosure provides pharmaceutical compositions and methods useful for modulating angiogenesis and for inhibiting metastasis, tumors, pulmonary alveolar proteinosis, and fibrosis in a mammalian tissue. Pharmaceutical compositions and methods include inhibitors of LOXL2 expression and activity, such as shRNA targeting LOXL2.
Claims13
An isolated polynucleotide, comprising:
- a first sequence comprising a nucleic acid sequence of SEQ ID NO:
- 21,
- a second sequence comprising a region of complementarity to the nucleic acid sequence of SEQ ID NO:
- 21, wherein the region of complementarity is at least 15 bases in length, and
- a linking sequence that joins the first sequence to the second sequence,
- wherein the polynucleotide forms a hairpin loop structure having a double-stranded stem region of between 15 and 49 base pairs in length that comprises the region of complementarity, wherein ends of the double-stranded stem region are connected by the linking sequence.
3 more elements
A pharmaceutical composition comprising:
- (a) a polynucleotide comprising a first sequence comprising a nucleic acid sequence of SEQ ID NO:
- 21, a second sequence comprising a region of complementarity to the nucleic acid sequence of SEQ ID NO:
- 21, wherein the region of complementarity is at least 15 bases in length, and a linking sequence that joins said first sequence to said second sequence, wherein the polynucleotide forms a hairpin loop structure having a double-stranded stem region of between 15 and 49 base pairs in length that comprises the region of complementarity, wherein ends of the double-stranded stem region are connected by the linking sequence;
- and
- (b) a pharmaceutical excipient.
2 more elements
Dependencies are inferred from the claim text.