Method for producing 4-oxoquinoline compound
AssigneeJapan Tobacco Inc.
InventorsKoji Matsuda, Koji Ando, Shigeji Ohki, Jun-ichi Hoshi, Takahiro Yamasaki
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Abstract
The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, for example, a compound represented by the formula (2′): wherein R is a fluorine atom or a methoxy group, and R400 is a hydrogen atom or a C1-C4 alkyl group, or a salt thereof, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.
Claims18
A method of producing a compound of the following formula (10):
- or a salt thereof, comprising reacting a compound of the following formula (8):
- wherein R100 is a C1-C4 alkyl group.
A method of producing a compound of the following formula (10):
- or a salt thereof, comprising reacting a compound of the following formula (2-2-B):
- wherein R300 is a C1-C4 alkyl group,
- to produce a compound of the following formula (2-3-B):
- or a salt thereof;
- reacting said compound of formula (2-3-B), or a salt thereof, to produce a compound of the following formula (3-B):
- reacting said compound of the formula (3-B) to produce a compound of the following formula (4-B):
- wherein R100 is a C1-C4 alkyl group,
- or a salt thereof;
- reacting said compound of the formula (4-B) to produce a compound of the following formula (5-B):
- wherein R100 is a C1-C4 alkyl group;
- reacting said compound of the formula (5-B) to produce a compound of the following formula (6-B):
- wherein R100 is a C1-C4 alkyl group;
- reacting said compound of the formula (6-B) to produce a compound of the following formula (8):
- wherein R100 is a C1-C4 alkyl group;
- and
- reacting said compound of the formula (8) to produce the above compound of the formula (10) or a salt thereof.
A compound of the following formula (8):
- wherein R100 is a C1-C4 alkyl group.
Dependencies are inferred from the claim text.