Mobilization of hematopoietic stem cells
AssigneeChildren's Hospital Medical Center
InventorYi Zheng
Life of this patent
Estimating the term…
Abstract
Methods, processes, uses, and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells and/or cancer stem cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as a Cdc-42 specific inhibitor alone or in combination with one or more additional agents. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve specific inhibition of the Cdc42 GTPase to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject.
Claims2
A method for mobilizing peripheral blood precursor cells from bone marrow into peripheral blood comprising:
- administering to a subject in need of treatment an effective amount of at least one Cdc42-specific inhibitor, wherein the Cdc42-specific inhibitor is CASIN.
A method for facilitating hematopoietic reconstitution of peripheral blood precursor cells in a subject's hematopoietic organs, comprising:
- a) administering to the subject an effective amount of at least one Cdc42-specific inhibitor in the precursor cells;
- b) isolating mobilized peripheral blood precursor cells from the peripheral circulation of the subject;
- and c) infusing the isolated mobilized peripheral blood precursor cells into the subject, wherein the Cdc42-specific inhibitor is CASIN.
Dependencies are inferred from the claim text.