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US 8,377,691 B2Granted
Lipoparticles comprising ion channels, methods of making and using the same
AssigneeIntegral Molecular, Inc.
InventorBenjamin J. Doranz
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Abstract
The present invention relates to the use of lipoparticles, virus-like particles, and viruses. The present invention also relates to testing ion channel function and modulators of ion channels.
Claims21
A method for identifying a test compound that can modulate ion conductance comprising:
- a) contacting an isolated virus particle purified away from a cell, the particle comprising an external lipid bilayer, a viral core protein, and a selected ion conductor with a membrane potential sensitive dye and a test compound;
- and
- b) detecting a change in membrane potential with the membrane potential sensitive dye,
- wherein a modulation in ion conductance in the presence of the test compound indicates that the test compound modulates ion conductance.
1 more element
Dependencies are inferred from the claim text.